Diverse biological activities of Thiazoles: A Retrospect

Many compounds bearing five membered heterocyclic rings in their structure have an extensive spectrum of biological activities. The search for new biologically active thiazole analogues continues to be an area of intensive investigation in medicinal chemistry. The present review describes ongoing research in search for new thiazole compounds that can prove useful for the design of future target and development of new drug molecule. *Corresponding author, Mailing address: Nadeem Siddiqui E-mail: [email protected], Tel: +91 1126059688 Extn 5639. Article History:-----------------------Date of Submission: 24-09-2011 Date of Acceptance: 24-11-2011 Conflict of Interest: NIL Source of Support: NONE R e v i e w P a p e r C o v e r e d i n I n d e x C o p e r n i c u s w i t h I C V a l u e 4 .6 8 f o r 2 0 1 0 Int. J. Drug Dev. & Res., Oct-Dec 2011, 3 (4): 55-67 Covered in Scopus & Embase, Elsevier 55 BIOLOGICAL ACTIVITIES Anticonvulsant activity Satoh et al[1] identified 4-fluoro-N-[4-[6(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]N-methyl benzamide (1) as a potent mGluR1 antagonist as PET tracer, it would have great potential for elucidation of mGluR1 functions in human. Agarwal et al[2] synthesized a series of 5-[(Nsubstituted benzylidenylimino)amino]-2-oxo/thiobarbituric acids and screened, in vivo for anticonvulsant and acute toxicity studies. The compounds (2a) and (2b) found to be more potent.